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EQUINE OXYGEN RESEARCH

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Toxicity Research:

The following tests were conducted by SGS U.S. Testing Company. The SGS network comprises more than 1,000 offices and laboratories and 37,000 employees, in well over 120 countries. It is one of the most respected testing labs in the world.

Creative Labs, Inc. of Boca Raton, Florida, conducted a series of thorough toxicity tests on Area International’s
H2O-BOO2STŪ EQUINE OXYGEN. The purpose of the tests was to determine if H2O-BOO2STŪ EQUINE OXYGEN had any ocular, dermal, inhalation or internal toxicity. To determine toxicity, safety tests were conducted on lab animals. The majority of test animals were rodents (primarily mice and rats). SGS tested H2O-BOO2STŪ EQUINE OXYGEN on Hartley Strain Albino Guinea Pigs, New Zealand Albino Rabbits and Sprague-Dawley Rats,

It is important to note that scientists have dramatically reduced the number of animals used in product safety testing. Animal rights activists have led the public to believe that the use of laboratory animals can be eliminated in this field altogether. It is often claimed that valid "alternatives" to the use of animal tests already exist to evaluate product safety. This is simply not true. In fact, companies that claim their products are not animal tested and, therefore, are "cruelty-free", mislead consumers, since almost all products, or the chemical compounds that comprise them, were at one time previously tested on animals.

While some “alternatives” to the use of animals have proven to be of value, the fact remains that most “alternatives” can only be used to screen for only a few toxic effects. In the final analysis, some animal models must be used. Not using animal tests would subject humans to unreasonable risks.

We believe that, as a manufacturer and distributor of nutritional and skin care products, we have both an ethical and a legal obligation to protect the safety of consumers. The purpose of safety (toxicity) testing is to ensure that a product is safe when used as directed. The results of these tests also provide scientific data for poison control centers and emergency room personnel should a product be misused.

“Acute Toxicity” is the ability of a substance to cause severe biological harm or death soon after a single exposure or dose. It also refers to any poisonous effect resulting from a single short-term exposure to a toxic substance. A poison, of course, is any substance that adversely affects someone's health by causing injury, illness, or death.

SGS conducted six different toxicity tests on
H2O-BOO2STŪ EQUINE OXYGEN. For purposes of these studies, the “lethal dose” (LD) or “lethal concentration” (LC) needed to be quantified. Once this amount had been determined, the amount was divided in half and was represented as half (50%) of the amount of a substance that can cause death when consumed or used. This is what is meant by the terms LD50 and LC50.

Of special note, in reviewing the tests conducted by SGS, is the fact that there were no reported incidences of death, (see necropsy findings,) for any of the laboratory animals. In fact, without exception, all of the laboratory animals exhibited healthy and weight gains indicating that
H2O-BOO2STŪ EQUINE OXYGEN did not have any adverse affect on normal metabolic functions.



The tests conducted by SGS were:

Acute Oral Toxicity Testing: This test determines whether a substance is toxic when consumed. There are three degrees defining oral toxicity: (1) Non-Toxic: The probable lethal dose of undiluted substance to 50% of the test animals determined from ingestion studies (LD50) is greater than 5 grams per kilogram of body weight; (2) Toxic: The probably lethal dose of undiluted substance to 50% of the test animals determined from ingestion studies (LD50) is greater than 50 milligrams and less than or equal to 5 grams per kilogram of body weight; (3) Highly Toxic: The probably lethal dose of undiluted substance to 50% of the test animals determined from ingestion studies (LD50) is less than or equal to 50 milligrams per kilogram of body weight.

Acute Dermal Toxicity Test (LD50): This test determines whether a substance posses the ability to become toxic to the skin. There are three different degrees defining acute dermal toxicity: (1) Non-Toxic: The lethal dose of the undiluted substance to 50% of the test animals determined from dermal toxicity studies (LD50) is greater than 2 grams per kilogram of body weight; (2) Toxic: The lethal dose of the undiluted substance to 50% of the test animals determined from dermal toxicity studies (LD50) is greater than 200 milligrams and less than or equal to 2 grams per kilogram of body weight: (3) Highly Toxic: The lethal dose of the undiluted substance to 50% of the test animals determined from dermal toxicity studies (LD50) is less than or equal to 200 milligrams per kilogram of body weight.

Acute Dermal Irritation/Corrosion Test: This test determines whether a substance can irritate or can be corrosive to the skin. There are four different degrees defining acute dermal irritation: (1) Practically Non-Irritating: The undiluted substance causes no noticeable irritation, or causes slight inflammation; (2) Moderately Irritating: The undiluted substance causes well-defined inflammation during the study period; (3) Primary Skin Irritant: The undiluted substance causes moderate to severe inflammation during the study period; (4) Corrosive: The undiluted substance causes visible destruction or irreversible alterations of the tissue structure at the site of contact during the study period.

Acute Inhalation (LC50) Toxicity Testing: This test determines whether a substance can be toxic when inhaled. There are three degrees defining acute inhalation toxicity: (1) Non-Toxic: The lethal concentration of the undiluted substance to 50% of the test animals (LC50) is greater than 200 milligrams per liter by volume when inhaled continuously for one hour or less; (2) Toxic: The lethal concentration of the undiluted substance to 50% of the test animals (LC50) is greater than 2 milligrams and less than or equal to 200 milligrams per liter by volume when inhaled continuously for one hour or less; (3) Highly Toxic: The lethal concentration of the undiluted product to 50% of the test animals (LC50) is less than or equal to 2 milligrams per liter by volume when inhaled continuously for one hour or less.

Skin Sensitization Test: This test determines whether a substance possesses a delayed-contact dermal sensitization response. There are four degrees defining skin sensitization: (1) Practically Non-Irritating: The undiluted substance causes no noticeable irritation, or causes slight inflammation; (2) Moderately Irritating: The undiluted substance causes well-defined inflammation during the study period; (3) Primary Skin Irritant: The undiluted substance causes moderate to severe inflammation during the study period; (4) Corrosive: The undiluted substance causes visible destruction or irreversible alterations of the tissue structure at the site of contact on the skin during the study period.

Eye Irritation Test: This test determines whether a substance irritates the eye. There are three degrees defining eye irritation: (1) Practically Non-Irritating: The undiluted substance, when instilled into the eyes produces no noticeable irritation, or slight transient conjunctival irritation; (2) Slightly Irritating: The undiluted substance, when instilled into the eyes, produces slight to moderate conjunctival irritation, slight corneal involvement, and/or slight iritis (the effects clear within 7 days); (3) Moderately Irritating: The undiluted substance, when instilled into the eyes, produces moderate corneal involvement with or without severe iritis. The effects clear within 21 days.


Here is a summary of SGS’s findings:

Acute Oral Toxicity Testing: “When tested as specified, the submitted test substance,
H2O-BOO2STŪ EQUINE OXYGEN at Full Strength Concentrated Solution, was determined to have an acute oral LD50 greater than 5.0 g/kg.” (Non-Toxic)

Acute Dermal Toxicity Test (LD50): “When tested as specified,
H2O-BOO2STŪ EQUINE OXYGEN at 20% Strength Concentrated Solution was not acutely toxic to the test animals following dermal application of the test substance at 2.0 g/kg.” (Non-Toxic)

Acute Dermal Irritation/Corrosion Test: “When tested as specified,
H2O-BOO2STŪ EQUINE OXYGEN at 20% Strength Concentrated Solution, did not induce dermal irritation in the six test animals following a 4-hour dermal exposure.” (Practically Non-Irritating)

Acute Inhalation (LC50) Toxicity Testing: “When tested as specified,
H2O-BOO2STŪ EQUINE OXYGEN at 40% Strength Concentrated Solution, was not acutely toxic to the test animals following a four hour inhalation exposure at a normal concentration of 23.9 mg/L (actual concentration was 14.6 mg/L). The LC50 was estimated to be greater than 23.9 mg/L (actual concentration was 14.6 mg/L).”

Skin Sensitization Test: “When tested as specified,
H2O-BOO2STŪ EQUINE OXYGEN at 20% Strength Concentrated Solution, was not considered to be a skin sensitizing agent. There were no significant differences in skin irritations observed in the test animals and in the control animals on challenge.”

Eye Irritation Test: “When tested as specified, the submitted test substance,
H2O-BOO2STŪ EQUINE OXYGEN at 20% Strength Concentrated Solution, was not an eye irritant.”


Conclusion:
In conclusion,
H2O-BOO2STŪ EQUINE OXYGEN was not found to be either toxic or an irritant to the skin, eyes or the respiratory system. Neither was the solution found to be toxic when consumed.

 

Additional Research On H2O-BOO2STŪ EQUINE OXYGEN
"Each subject's partial pressure of oxygen was relatively stable prior to consumption, but then rose immediately after consumption. The partial pressure of oxygen peaked 90 to 120 minutes after consumption, after which it gradually dropped, reaching its pre-consumption level. In a subject with a particularly low baseline, a significant increase was observed." (Suntory study: May 1996)

 


NOTICE: This information is intended for educational purposes only and should not be construed as medical advice. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified veterinarian before using any nutritional supplements on your horses.

This information may not be reproduced or utilized in any form or by any means, in whole or in part, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without prior written permission. 

Racing picture above is called “GALLOWAY & COMPANY”  from the Collection of Randy Galloway and Don Walker.

 

 

Đ 2009 H2O-BOO2STŪ AQUACEUTICALS